Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The spleen combines the innate and adaptive immune system in a uniquely organized way.
The structure of the spleen enables it to remove older erythrocytes from the circulation and …

Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily
(TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and inflammatory …

Members of the tumour necrosis factor (TNF) receptor superfamily have important functions
in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex …

Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of
B-cell antigen encounter and differentiation. CXC chemokine receptor-5 (CXCR5) is …

Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes
and Peyer's patches. We show here that during fetal life the nuclear hormone receptor …

The members of the tumour necrosis factor (TNF)/tumour necrosis factor receptor (TNFR)
superfamily are critically involved in the maintenance of homeostasis of the immune system …

The diversity of COVID-19 disease in otherwise healthy people, from seemingly
asymptomatic infection to severe life-threatening disease, is not clearly understood. We …