The role of novel biomarker HE4 in the diagnosis, prognosis and follow-up of ovarian cancer: a systematic review

G Scaletta, F Plotti, D Luvero… - Expert review of …, 2017 - Taylor & Francis
Introduction: Ovarian cancer is the leading cause of death from gynecologic cancers, in
fact,> 80% of cases are diagnosed as advanced-stage disease associated with a high …

[HTML][HTML] The emerging role of HE4 in the evaluation of advanced epithelial ovarian and endometrial carcinomas

AR Simmons, K Baggerly, RC Bast Jr - Oncology (Williston Park …, 2013 - ncbi.nlm.nih.gov
Abstract HE4 (human epididymis protein 4) is overexpressed in both ovarian and
endometrial cancers. Levels of the shed HE4 protein are elevated in sera from ovarian and …

An all-graphene quantum dot Förster resonance energy transfer (FRET) probe for ratiometric detection of HE4 ovarian cancer biomarker

G Bharathi, F Lin, L Liu, TY Ohulchanskyy, R Hu… - Colloids and Surfaces B …, 2021 - Elsevier
Ovarian cancer (OVC), the most lethal form of all gynecological cancers, is a big threat to
women's health. Late diagnosis at the advanced stages is one of the major reasons for the …

[HTML][HTML] Early clearance of serum HE4 and CA125 in predicting platinum sensitivity and prognosis in epithelial ovarian cancer

Y Rong, L Li - Journal of ovarian research, 2021 - Springer
Objectives To assess the clinical value of early clearance of HE4 and CA125 for platinum
sensitivity and prognosis in patients with ovarian cancer. Method HE4 and CA125 value …

Role of human epididymis protein 4 in chemoresistance and prognosis of epithelial ovarian cancer

S Lee, S Choi, Y Lee, D Chung… - Journal of Obstetrics …, 2017 - Wiley Online Library
Aim Human epididymis protein 4 (HE4) is a novel biomarker for epithelial ovarian cancer.
This study was designed to evaluate the role of HE4 in chemo‐response against anti‐cancer …

Development of a multimarker assay for differential diagnosis of benign and malignant pelvic masses

X Chen, H Zhou, R Chen, J He, Y Wang, L Huang… - Clinica Chimica …, 2015 - Elsevier
Background HE4, a novel tumor marker for detecting ovarian cancer, has been recently
applied to clinical practice. However, the comprehensive evaluation of HE4 combined with …

[PDF][PDF] Diagnostic performances of CA125, HE4, and ROMA index in ovarian cancer

ZG Dikmen, A Colak, P Dogan, S Tuncer… - Eur J Gynaecol …, 2015 - article.imrpress.com
Purpose of investigation: HE4 (human epididymis protein 4) is suggested to be used as a
potential new biomarker to identify ovarian malignancies from benign adnexal masses. The …

[HTML][HTML] Performance of preoperative plasma tumor markers HE4 and CA125 in predicting ovarian cancer mortality in women with epithelial ovarian cancer

D Furrer, J Gregoire, S Turcotte, M Plante… - PLoS …, 2019 - journals.plos.org
Clinical utility of new biomarkers often requires the identification of their optimal threshold.
This external validation study was conducted to assess the performance of the preoperative …

Pillar[6]arene@AuNPs Functionalized N-CQDs@Co3O4 Hybrid Composite for Ultrasensitive Electrochemical Detection of Human Epididymis Protein 4

Z Ran, H Yang, Z Li, K Wang, J Zhao… - ACS Sustainable …, 2020 - ACS Publications
Hydroxylatopillar [6] arene (HP6) has been used as a stable ligand for the synthesis of gold
nanoparticles (AuNPs). HP6 with excellent molecular recognition capability will securely …

[HTML][HTML] Could HE4 level measurements during first-line chemotherapy predict response to treatment among ovarian cancer patients?

A Chudecka-Głaz, A Cymbaluk-Płoska, M Wężowska… - PloS one, 2018 - journals.plos.org
Background This study assessed the prognostic value of HE4 marker measurements at
various stages of first-line chemotherapy for ovarian cancer. Methods The study consisted of …