Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets

F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Eosinophilic gastrointestinal disorders pathology

MH Collins, K Capocelli, GY Yang - Frontiers in medicine, 2018 - frontiersin.org
Eosinophilic gastrointestinal disorders (EGID) are characterized pathologically by excess
eosinophils in mucosal biopsies of one or multiple sites in the gastrointestinal (GI) tract …

DNA methylation in nasal epithelium, atopy, and atopic asthma in children: a genome-wide study

E Forno, T Wang, C Qi, Q Yan, CJ Xu… - The lancet Respiratory …, 2019 - thelancet.com
Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis

M Pal, S Bhattacharya, G Kalyan, S Hazra - Experimental cell research, 2018 - Elsevier
The major hallmarks of Epithelial-Mesenchymal Transition (EMT) is the loss of epithelial cell
polarity and loss of expression of the cell-cell adhesion molecule like E-cadherin and …

Epithelial origin of eosinophilic esophagitis

M Rochman, NP Azouz, ME Rothenberg - Journal of Allergy and Clinical …, 2018 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the
esophagus characterized predominantly by eosinophilic inflammation, leading to …

Comprehensive analysis of nasal polyps reveals a more pronounced type 2 transcriptomic profile of epithelial cells and mast cells in aspirin-exacerbated respiratory …

C Bangert, S Villazala-Merino, M Fahrenberger… - Frontiers in …, 2022 - frontiersin.org
Chronic rhinosinusitis with nasal polyps is affecting up to 3% of Western populations. About
10% of patients with nasal polyps also suffer from asthma and intolerance to aspirin, a …

Beyond the matrix: the many non-ECM ligands for integrins

B LaFoya, JA Munroe, A Miyamoto… - International journal of …, 2018 - mdpi.com
The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …

Synaptic processes and immune-related pathways implicated in Tourette syndrome

F Tsetsos, D Yu, JH Sul, AY Huang, C Illmann… - Translational …, 2021 - nature.com
Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture
involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie …

A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome

J Jacobse, R Brown, F Revetta, M Vaezi… - Journal of Allergy and …, 2024 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic immune mediated inflammatory
disorder of the esophagus. It is still unknown why children and adults present differently, and …

Molecular mechanisms of eosinophilic esophagitis

YV Zhernov, SO Vysochanskaya, VA Sukhov… - International Journal of …, 2021 - mdpi.com
Food hypersensitivity is a group of diseases arising from a specific immune response that
reproduces on exposure to a given food. The current understanding of molecular …