Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …

Background Human skeletal muscle is composed of three major fiber types, referred to as
type 1, 2A, and 2X fibers. This heterogeneous cellular composition complicates the …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic
contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove …

Autophagy provides nutrients during starvation and eliminates detrimental cellular
components. However, accumulating evidence indicates that autophagy is not merely a …

The complex morphology of neurons, the specific requirements of synaptic
neurotransmission and the accompanying metabolic demands create a unique challenge for …

Multiple aspects of neuronal physiology crucially depend on two cellular pathways,
autophagy and endocytosis. During endocytosis, extracellular components either unbound …

Autophagy is a constitutive pathway that allows the lysosomal degradation of damaged
components. This conserved process is essential for metabolic plasticity and tissue …