Mass spectrometry is well-established as one of the primary methods used to characterize
peptides and proteins. New advances in instrumentation and innovative analytical workflows …

Studies of large proteins, protein complexes, and membrane protein complexes pose new
challenges, most notably the need for increased ion mobility (IM) and mass spectrometry …

The activation of G proteins by G protein-coupled receptors (GPCRs) underlies the majority
of transmembrane signaling by hormones and neurotransmitters. Recent structures of GPCR …

The abnormal self-assembly of β-amyloid (Aβ) peptides and their deposition in the brain is a
major pathological feature of Alzheimer's disease (AD), the most prevalent chronic …

Rotationally averaged collision cross section (CCS) values for a series of proteins and
protein complexes ranging in size from 8.6 to 810 kDa are reported. The CCSs were …

Covalent labeling with mass spectrometry is increasingly being used for the structural
analysis of proteins. Diethylpyrocarbonate (DEPC) is a simple to use, commercially …

The stability of proteins influences their tendency to aggregate, undergo degradation, or
become modified in cells. Despite their significance to understanding protein folding and …

The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …

prostaglandin dehydrogenase (15-PGDH) is a negative regulator of tissue stem cells that
acts via enzymatic activity of oxidizing and degrading PGE2, and related eicosanoids, that …

Structural biology is entering an exciting time where many new high-resolution structures of
large complexes and membrane proteins are determined regularly. These advances have …