Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

Cancer is a multifactorial process associated with changes in signaling pathways leading to
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …

Inflammation is a common condition of prostate tissue, whose impact on carcinogenesis is
highly debated. Microbial colonization is a well-documented cause of a small percentage of …

TRPM8 has recently emerged as a druggable target in prostate cancer (PC) and TRPM8
modulators have been proposed as potential anticancer agents in this pathology. We have …

ABSTRACT Introduction The Ca2+ signaling toolkit is currently under investigation as a
potential target for addressing the threat of cancer. A growing body of evidence suggests …

Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial
roles in body axis orientation and tissue differentiation, including in the reproductive system …

The transient receptor potential melastatin (TRPM) channel family has been previously
implicated in various diseases, including those related to temperature sensing …

Ion channels have major regulatory functions in living cells. Apart from their role in ion
transport, they are responsible for cellular electrogenesis and excitability, and may also …

Prostate cancer (PCa) is the second deadliest cancer among men worldwide. Particularly
critical is its development towards metastatic androgen-independent forms for which the …

TRPM8 is a non-selective cation channel expressed in primary sensory neurons and other
tissues, including the prostate and urothelium. Its participation in different physiological and …