Tissue engineering is a promising strategy to treat tissue and organ loss or damage caused
by injury or disease. During the past two decades, mesenchymal stem cells (MSCs) have …

Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like
growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 …

Articular cartilage repair and regeneration continue to be largely intractable because of the
poor regenerative properties of this tissue. The field of articular cartilage tissue engineering …

Background Damaged articular cartilage has limited capacity for self-repair. Autologous
chondrocyte implantation using a characterized cell therapy product results in significantly …

With the emerging interest in regenerative medicine and tissue engineering, new treatment
modalities being developed for joint disorders including joint surface lesions and articular …

Articular cartilage is composed of chondrons within a territorial matrix surrounded by a
highly organized extracellular matrix comprising collagen II fibrils, proteoglycans …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …

Background: There are currently several approaches being pursued to treat focal defects of
articular cartilage, each having specific advantages or challenges. A single-stage procedure …

Thiolated chitosan (CS-NAC) was synthesized and the selected CS-NAC was used together
with silk fibroin (SF) to produce dual network CS-NAC/SF hydrogels. The CS-NAC/SF …

Articular cartilage is easily injured but difficult to repair and cell therapies are proposed as
tools to regenerate the defects in the tissue. Both differentiated chondrocytes and adult …