Background Botulinum neurotoxin (BoNT) produced by Clostridium botulinum is one of the
most potent known toxins. Moreover, BoNT is classified as one of the most important …

Pathological tau aggregates propagate across functionally connected neuronal networks in
human neurodegenerative pathologies, such as Alzheimer's disease. However, the …

Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the
intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral …

The sperm acrosome is a large dense-core granule whose contents are secreted by
regulated exocytosis at fertilization through the opening of numerous fusion pores between …

Local tetanus develops when limited amounts of tetanus neurotoxin (TeNT) are released by
Clostridium tetani generated from spores inside a necrotic wound. Within days, a spastic …

For a long time, a widely used method for tetanus toxoid (Ttd) potency has been the
challenge test, in which animals are immunized and then challenged with tetanus toxin in …

The huge advances in genomics and molecular biology in the past two decades have made
now an exciting time to study bacterial toxins, in particular, the most potent bacterial toxin …

Background and Objectives: Local inhibitory circuits and long-range inhibitory projections
within the interconnected basal ganglia nuclei are critical for control of voluntary movement …