DNA has played an early and powerful role in the development of bottom-up
nanotechnologies, not least because of DNA's precise, predictable, and controllable …

In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …

Background: Repeats of O n sequences are detected as single strand overhangs at the ends
of eukaryotic chromosomes together with associated binding proteins. Such telomere …

Molecular self‐assembly is central to many processes in both biology and supramolecular
chemistry. The G‐quartet, a hydrogen‐bonded macrocycle formed by cation‐templated …

Synthetic biologists come in two broad classes. One uses unnatural molecules to reproduce
emergent behaviours from natural biology, with the goal of creating artificial life. The other …

Most eukaryotic telomeres contain a repeating motif with stretches of guanine residues that
form a 3′-terminal overhang extending beyond the telomeric duplex region. The telomeric …

The human parvovirus, adeno‐associated virus (AAV), has been shown to integrate
preferentially into human chromosome 19 q13. 3‐qter. The human target sequence for AAV …

BLM, the gene that is defective in Bloom's syndrome, encodes a protein homologous to
RecQ subfamily helicases that functions as a 3′-5′ DNA helicase in vitro. We now report …

Guanine rich DNA has been known for decades to form unusual structures, although their
biological relevance was little understood. Recent advances have demonstrated that …

Several molecular technologies aimed at regulating gene expression that have been
recently developed as a strategy to combat inflammatory and neoplastic diseases. Among …