Insulin resistance (IR) plays a key role in the pathophysiology of obesity-related diseases
such as type 2 diabetes and nonalcoholic fatty liver disease. It has been demonstrated that …

Endothelium is the largest organ in the body strategically located between the wall of blood
vessels and the blood stream. The human body contains approximately 1013 endothelial …

Premature cardiovascular disease (CVD), including stroke, peripheral vascular disease,
sudden death, coronary artery disease, and congestive heart failure, is a notorious problem …

During the past 2 decades, results of both basic science and clinical studies have changed
the physicians' views about adipocyte pathophysiology. Since leptin was discovered in …

Adipose tissue is acknowledged as an endocrine organ that releases bioactive factors
termed adipokines. Visfatin was initially identified as a novel adipokine with insulin‐mimetic …

Background Obesity poses significant challenges to healthcare globally, particularly through
its bi‐directional relationship with co‐morbid metabolic conditions such as type 2 diabetes …

Visfatin is a newly discovered adipocyte hormone with a direct relationship between plasma
visfatin level and type 2 diabetes mellitus. Visfatin binds to the insulin receptor at a site …

Obesity and obesity-related disorders play an important role in clinical medicine. Adipose
tissue, with its soluble mediators called adipocytokines, has emerged as a major endocrine …

Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and
is associated with an increased death risk from cardiovascular diseases. However, while …

Context: Recently, vaspin was identified as an insulin-sensitizing adipokine. However,
regulation of this adipocyte-secreted factor in human disease has not been determined …