The molecular biology of FMRP: new insights into fragile X syndrome
JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …
[PDF][PDF] A synaptic perspective of fragile X syndrome and autism spectrum disorders
C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
complex genetic architectures but overlapping behavioral phenotypes, which suggests …
PSD95: A synaptic protein implicated in schizophrenia or autism?
AA Coley, WJ Gao - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …
brain are currently being investigated as one of the major etiologies of neurodevelopmental …
[PDF][PDF] Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
regulation of RNA processing and transport. Alterations of these proteins impact multiple …
Dendritic spines: the locus of structural and functional plasticity
C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …
changed dramatically the rate of progress towards the understanding of the complex …
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
Abstract N 6-methyladenosine (m6A) is the most prevalent internal modification of
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological …
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological …
Lessons learned from studying syndromic autism spectrum disorders
Y Sztainberg, HY Zoghbi - Nature neuroscience, 2016 - nature.com
Syndromic autism spectrum disorders represent a group of childhood neurological
conditions, typically associated with chromosomal abnormalities or mutations in a single …
conditions, typically associated with chromosomal abnormalities or mutations in a single …
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
A Yoshii, M Constantine‐Paton - Developmental neurobiology, 2010 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse
developmental events from the selection of neural progenitors to the terminal dendritic …
developmental events from the selection of neural progenitors to the terminal dendritic …