The molecular biology of FMRP: new insights into fragile X syndrome

JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

[PDF][PDF] A synaptic perspective of fragile X syndrome and autism spectrum disorders

C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

RNA G-quadruplexes (rG4s): genomics and biological functions

K Lyu, EYC Chow, X Mou, TF Chan… - Nucleic acids …, 2021 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

PSD95: A synaptic protein implicated in schizophrenia or autism?

AA Coley, WJ Gao - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the
brain are currently being investigated as one of the major etiologies of neurodevelopmental …

[PDF][PDF] Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions

JK Nussbacher, R Tabet, GW Yeo, C Lagier-Tourenne - Neuron, 2019 - cell.com
RNA binding proteins are critical to the maintenance of the transcriptome via controlled
regulation of RNA processing and transport. Alterations of these proteins impact multiple …

Dendritic spines: the locus of structural and functional plasticity

C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets

F Zhang, Y Kang, M Wang, Y Li, T Xu… - Human molecular …, 2018 - academic.oup.com
Abstract N 6-methyladenosine (m6A) is the most prevalent internal modification of
mammalian messenger RNAs (mRNAs) and long non-coding RNAs. The biological …

Lessons learned from studying syndromic autism spectrum disorders

Y Sztainberg, HY Zoghbi - Nature neuroscience, 2016 - nature.com
Syndromic autism spectrum disorders represent a group of childhood neurological
conditions, typically associated with chromosomal abnormalities or mutations in a single …

Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease

A Yoshii, M Constantine‐Paton - Developmental neurobiology, 2010 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse
developmental events from the selection of neural progenitors to the terminal dendritic …