Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Questions and controversies in the study of time-varying functional connectivity in resting fMRI
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing …
Knowledge of the spatiotemporal organization of these interactions is critical for establishing …
Global waves synchronize the brain's functional systems with fluctuating arousal
We propose and empirically support a parsimonious account of intrinsic, brain-wide
spatiotemporal organization arising from traveling waves linked to arousal. We hypothesize …
spatiotemporal organization arising from traveling waves linked to arousal. We hypothesize …
A tripartite view of the posterior cingulate cortex
The posterior cingulate cortex (PCC) is one of the least understood regions of the cerebral
cortex. By contrast, the anterior cingulate cortex has been the subject of intensive …
cortex. By contrast, the anterior cingulate cortex has been the subject of intensive …
[HTML][HTML] Hierarchical heterogeneity across human cortex shapes large-scale neural dynamics
The large-scale organization of dynamical neural activity across cortex emerges through
long-range interactions among local circuits. We hypothesized that large-scale dynamics are …
long-range interactions among local circuits. We hypothesized that large-scale dynamics are …
Challenges and future directions for representations of functional brain organization
A key principle of brain organization is the functional integration of brain regions into
interconnected networks. Functional MRI scans acquired at rest offer insights into functional …
interconnected networks. Functional MRI scans acquired at rest offer insights into functional …
[HTML][HTML] What have we really learned from functional connectivity in clinical populations?
Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …
[HTML][HTML] Connectomics of human electrophysiology
We present both a scientific overview and conceptual positions concerning the challenges
and assets of electrophysiological measurements in the search for the nature and functions …
and assets of electrophysiological measurements in the search for the nature and functions …
[HTML][HTML] Resting-state “physiological networks”
Slow changes in systemic brain physiology can elicit large fluctuations in fMRI time series,
which manifest as structured spatial patterns of temporal correlations between distant brain …
which manifest as structured spatial patterns of temporal correlations between distant brain …
Dissociations between glucose metabolism and blood oxygenation in the human default mode network revealed by simultaneous PET-fMRI
The finding of reduced functional MRI (fMRI) activity in the default mode network (DMN)
during externally focused cognitive control has been highly influential to our understanding …
during externally focused cognitive control has been highly influential to our understanding …