The most commonly used treatment for Parkinson's disease (PD) is levodopa, prescribed in
conjunction with carbidopa. Virtually all patients with PD undergo dopamine replacement …

Neuroimaging has revolutionized our understanding of brain function and has become an
essential tool for researchers studying neurological disorders. Functional magnetic …

The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of
substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe …

Fat grafting is a well-established surgical technique used in plastic surgery to restore
deficient tissue, and more recently, for its putative regenerative properties. Despite more …

The basal ganglia are essential for executing motor actions. How the basal ganglia engage
spinal motor networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons …

Somatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In
the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein …

Rhythmic neural network activity has been broadly linked to behavior. However, it is unclear
how membrane potentials of individual neurons track behavioral rhythms, even though …

Direct reprogramming based on genetic factors resembles a promising strategy to replace
lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a …

Freezing of gait is a debilitating symptom in advanced Parkinson's disease and responds
heterogeneously to treatments such as deep brain stimulation. Recent studies indicated that …

The spreading of misfolded alpha-synuclein (α-syn) protein has been observed in animal
models of Parkinson's disease (PD) and other α-synucleinopathies that mimic human PD …