Highlights•Enzymerhodopsins are a novel class of microbial rhodopsin-based
photoreceptors.•Enzymerhodopsins enable light-regulation of enzymatic functions.•They …

Class III adenylate cyclases (ACs) are widespread signaling proteins, which translate
diverse intracellular and extracellular stimuli into a uniform intracellular signal. They are …

Light perception for orientation in zoospore-forming fungi is linked to homo-or heterodimeric
rhodopsin-guanylyl cyclases (RGCs). Heterodimeric RGCs, first identified in the chytrid …

Organisms adapt to environmental cues using diverse signaling networks. In order to sense
and integrate light for regulating various biological functions, photoreceptor proteins have …

Genetically targeting biological systems to control cellular processes with light is the concept
of optogenetics. Despite impressive developments in this field, underlying molecular …

There is a growing appreciation for the idea that bacterial utilization of host-derived lipids,
including cholesterol, supports Mycobacterium tuberculosis (Mtb) pathogenesis. This has …

Nucleotidyl cyclases, including membrane-integral and soluble adenylyl and guanylyl
cyclases, are central components in a wide range of signaling pathways. These proteins are …

Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor
of the mammalian membrane ACs and a model system for studies of their structure and …

Membrane adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second
messenger cAMP. As effector proteins of G protein-coupled receptors and other signaling …

Enzymerhodopsins represent a recently discovered class of rhodopsins which includes
histidine kinase rhodopsin, rhodopsin phosphodiesterases, and rhodopsin guanylyl …