Illuminating dendritic function with computational models

P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Dendritic integration: 60 years of progress

GJ Stuart, N Spruston - Nature neuroscience, 2015 - nature.com
Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

Connectomic reconstruction of the inner plexiform layer in the mouse retina

M Helmstaedter, KL Briggman, SC Turaga, V Jain… - Nature, 2013 - nature.com
Comprehensive high-resolution structural maps are central to functional exploration and
understanding in biology. For the nervous system, in which high resolution and large spatial …

Feature detection by retinal ganglion cells

D Kerschensteiner - Annual review of vision science, 2022 - annualreviews.org
Retinal circuits transform the pixel representation of photoreceptors into the feature
representations of ganglion cells, whose axons transmit these representations to the brain …

Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity

J Cichon, WB Gan - Nature, 2015 - nature.com
The brain has an extraordinary capacity for memory storage, but how it stores new
information without disrupting previously acquired memories remains unknown. Here we …

The neuronal organization of the retina

RH Masland - Neuron, 2012 - cell.com
The mammalian retina consists of neurons of> 60 distinct types, each playing a specific role
in processing visual images. They are arranged in three main stages. The first decomposes …

A visual motion detection circuit suggested by Drosophila connectomics

S Takemura, A Bharioke, Z Lu, A Nern, S Vitaladevuni… - Nature, 2013 - nature.com
Animal behaviour arises from computations in neuronal circuits, but our understanding of
these computations has been frustrated by the lack of detailed synaptic connection maps, or …

Space–time wiring specificity supports direction selectivity in the retina

JS Kim, MJ Greene, A Zlateski, K Lee, M Richardson… - Nature, 2014 - nature.com
How does the mammalian retina detect motion? This classic problem in visual neuroscience
has remained unsolved for 50 years. In search of clues, here we reconstruct Off-type …

Calcium signalling: dynamics, homeostasis and remodelling

MJ Berridge, MD Bootman, HL Roderick - Nature reviews Molecular …, 2003 - nature.com
Ca 2+ is a highly versatile intracellular signal that operates over a wide temporal range to
regulate many different cellular processes. An extensive Ca 2+-signalling toolkit is used to …

Wiring specificity in the direction-selectivity circuit of the retina

KL Briggman, M Helmstaedter, W Denk - Nature, 2011 - nature.com
The proper connectivity between neurons is essential for the implementation of the
algorithms used in neural computations, such as the detection of directed motion by the …