Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …

Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …

Human endogenous retroviruses (HERV) have been implicated in a variety of diseases
including cancers. Recent research implicates HERVs in epigenetic gene regulation. Here …

Simple Summary Human endogenous retrovirus (HERV) plays important roles in the
development of cancer, and most studies use data from The Cancer Genome Atlas to …

Epigenetic drugs are used for the clinical treatment of hematologic malignancies; however,
their therapeutic potential in solid tumors is still under investigation. Current evidence …

At the outbreak of the COVID-19 global crisis, diverse scientific groups suggested that this
unprecedented emergency could act as a 'blessing in disguise'. In the aftermath of the …

Methods: We assessed whether genetic variation in TET2 was associated with markers of
HIV-pathogenesis using both gene level and single nucleotide polymorphism (SNP) level …

Microbiome, including bacteria, fungi, and viruses, plays a crucial role in shaping distal and
proximal anti-tumor immunity. Mounting evidence showed that commensal microbiome …

Background Endogenous retroviruses (ERVs) are the result of the integration of retroviruses
into host DNA following germline infection. Endogenous retroviruses are made up of three …

Ewing Sarcoma (EwS) is a non-T cell-inflamed, pediatric bone and soft tissue tumor with
high metastatic capacity. Here, we show that EwS extracellular vesicles (EVs) elicit a pro …