The untapped potential of ascites in ovarian cancer research and treatment
The build-up of fluid in the peritoneal cavity—ascites—is a hallmark of ovarian cancer, the
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …
most lethal of all gynaecological malignancies. This remarkable fluid, which contains a …
[HTML][HTML] Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment
E Schoutrop, L Moyano-Galceran, S Lheureux… - Seminars in cancer …, 2022 - Elsevier
Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …
[HTML][HTML] SCD1/FADS2 fatty acid desaturases equipoise lipid metabolic activity and redox-driven ferroptosis in ascites-derived ovarian cancer cells
Rationale: Malignant ascites in peritoneal metastases is a lipid-enriched microenvironment
and is frequently involved in the poor prognosis of epithelial ovarian cancer (EOC) …
and is frequently involved in the poor prognosis of epithelial ovarian cancer (EOC) …
Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment
Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the
management of solid tumor malignancies. In ovarian cancer, this is in part due to an …
management of solid tumor malignancies. In ovarian cancer, this is in part due to an …
Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
[HTML][HTML] Integrated analysis of ascites and plasma extracellular vesicles identifies a miRNA-based diagnostic signature in ovarian cancer
Ovarian cancer is mostly diagnosed at advantaged stages due to the lack of early diagnostic
biomarkers. The common metastasis pattern is characterized by peritoneal dissemination …
biomarkers. The common metastasis pattern is characterized by peritoneal dissemination …
Tumor evolution and chemoresistance in ovarian cancer
Abstract Development of novel strategies to overcome chemoresistance is central goal in
ovarian cancer research. Natural history of the cancer development and progression is …
ovarian cancer research. Natural history of the cancer development and progression is …
Multicellular detachment generates metastatic spheroids during intra-abdominal dissemination in epithelial ovarian cancer
Ovarian cancer is the most lethal gynecological cancer, where survival rates have had
modest improvement over the last 30 years. Metastasis of cancer cells is a major clinical …
modest improvement over the last 30 years. Metastasis of cancer cells is a major clinical …
Deregulation of lipid metabolism: the critical factors in ovarian cancer
Z Ji, Y Shen, X Feng, Y Kong, Y Shao, J Meng… - Frontiers in …, 2020 - frontiersin.org
Ovarian cancer is one of the most malignant gynecological cancers around the world. In
spite of multiple treatment options, the five-year survival rate is still very low. Several …
spite of multiple treatment options, the five-year survival rate is still very low. Several …
Ovarian cancer stem cells: still an elusive entity?
M Lupia, U Cavallaro - Molecular cancer, 2017 - Springer
The cancer stem cell (CSC) model proposes that tumor development and progression are
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …
fueled and sustained by undifferentiated cancer cells, endowed with self-renewal and tumor …