The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …

Transcription-replication conflict is a major cause of replication stress that arises when
replication forks collide with the transcription machinery. Replication fork stalling at sites of …

Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop
formation are known to impede S phase progression. Nonetheless, cancer cells …

An important advance in cancer therapy has been the development of poly (ADP-ribose)
polymerase (PARP) inhibitors for the treatment of homologous recombination (HR)-deficient …

Antioxidants can help trap and neutralize free reactive oxygen species to reduce their
damage. Thus, it is important to evaluate the content of antioxidants in foods and drugs. In …

Replication forks stalled at co-transcriptional R-loops can be restarted by a mechanism
involving fork cleavage-religation cycles mediated by MUS81 endonuclease and DNA …

Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis,
therapy resistance and metastasis. Radiobiological hypoxia (< 0.1% O2) is one of the few …

R‐loops represent a major source of replication stress, but the mechanism by which these
structures impede fork progression remains unclear. To address this question, we monitored …

Replication stress (RS) is a key trait of cancer cells, and a potential actionable target in
cancer treatment. Accurate methods to measure RS in tumour samples are currently lacking …

Transcription-replication conflicts (TRCs) induce formation of cotranscriptional RNA: DNA
hybrids (R-loops) stabilized by G-quadruplexes (G4s) on the displaced DNA strand, which …