[HTML][HTML] Paternal genome elimination: patterns and mechanisms of drive and silencing

M Herbette, L Ross - Current Opinion in Genetics & Development, 2023 - Elsevier
In thousands of arthropod species, males inherit, but subsequently eliminate the entire
haploid genome of their father. However, why this peculiar reproductive strategy evolved …

New perspectives on the causes and consequences of male meiotic drive

C Courret, X Wei, AM Larracuente - Current Opinion in Genetics & …, 2023 - Elsevier
Gametogenesis is vulnerable to selfish genetic elements that bias their transmission to the
next generation by cheating meiosis. These so-called meiotic drivers are widespread in …

Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans

J Vedanayagam, M Herbette, H Mudgett, CJ Lin… - PLoS …, 2023 - journals.plos.org
Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own
transmission even in the face of severe fitness costs to their host organism. However …

Derepression of Y-linked multicopy protamine-like genes interferes with sperm nuclear compaction in D. melanogaster

JI Park, GW Bell, YM Yamashita - Proceedings of the …, 2023 - National Acad Sciences
Across species, sperm maturation involves the dramatic reconfiguration of chromatin into
highly compact nuclei that enhance hydrodynamic ability and ensure paternal genomic …

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

M De Carvalho, GS Jia, AN Srinivasa, RB Billmyre… - Elife, 2022 - elifesciences.org
Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …

Asymmetric inheritance: the diversity and evolution of non-Mendelian reproductive strategies

L Ross, AJ Mongue, CN Hodson… - Annual Review of …, 2022 - annualreviews.org
The ability to reproduce is the key trait that distinguishes living organisms from inorganic
matter, and the strategies used to achieve successful reproduction are almost as diverse as …

Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts

J Vedanayagam, CJ Lin, R Papareddy, M Nodine… - Plos …, 2023 - journals.plos.org
Although the biological utilities of endogenous RNAi (endo-RNAi) have been largely
elusive, recent studies reveal its critical role in the non-model fruitfly Drosophila simulans to …

[HTML][HTML] Diverse genetic conflicts mediated by molecular mimicry and computational approaches to detect them

SL Russell, G Penunuri, C Condon - Seminars in Cell & Developmental …, 2025 - Elsevier
In genetic conflicts between intergenomic and selfish elements, driver and killer elements
achieve biased survival, replication, or transmission over sensitive and targeted elements …

Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter

M Vitale, N Kranjc, J Leigh, K Kyrou, T Courty… - PLoS …, 2024 - journals.plos.org
Despite efforts to explore the genome of the malaria vector Anopheles gambiae, the Y
chromosome of this species remains enigmatic. The large number of repetitive and …

Running the gauntlet: challenges to genome integrity in spermiogenesis

M Kitaoka, YM Yamashita - Nucleus, 2024 - Taylor & Francis
Species' continuity depends on gametogenesis to produce the only cell types that can
transmit genetic information across generations. Spermiogenesis, which encompasses post …