tRNAs undergo an extensive maturation process including posttranscriptional modifications
that influence secondary and tertiary interactions. Precursor and mature tRNAs lacking key …

The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of
four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all …

tRNAs undergo an extensive maturation process involving posttranscriptional modifications
often associated with tRNA structural stability and promoting the native fold. Impaired …

The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …

Nascent pre-tRNAs are transcribed by RNA polymerase III and immediately bound by La
proteins on the UUU-3'OH sequence, using a tandem arrangement of the La motif and an …

Splicing requires the tight coordination of dynamic spliceosomal RNAs and proteins. U6 is
the only spliceosomal RNA transcribed by RNA Polymerase III and undergoes an extensive …

Abstract Kinase, putative Endopeptidase, and Other Proteins of Small size (KEOPS) is a
multisubunit protein complex conserved in eukaryotes and archaea. It is composed of Pcc1 …

Efficient splicing requires the tight coordination of dynamic spliceosomal RNAs and proteins.
U6 is the only spliceosomal RNA transcribed by RNA Polymerase III and undergoes an …

The telomerase holoenzyme is critical for maintaining eukaryotic genome integrity. In
addition to a reverse transcriptase and an RNA template, telomerase contains additional …

Double-stranded DNA break (DSB) repair is a fundamental process for all cellular life.
Recently, KEOPS, a multiple-subunit protein complex that is conserved in eukaryotes and …