Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Abstract Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed
in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a …

Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including
intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of …

The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …

Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …