Major depressive disorder

W Marx, BWJH Penninx, M Solmi… - Nature Reviews …, 2023 - nature.com
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

AJ McGuinness, JA Davis, SL Dawson… - Molecular …, 2022 - nature.com
The emerging understanding of gut microbiota as 'metabolic machinery'influencing many
aspects of physiology has gained substantial attention in the field of psychiatry. This is …

Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders

J Horn, DE Mayer, S Chen, EA Mayer - Translational psychiatry, 2022 - nature.com
There is emerging evidence that diet has a major modulatory influence on brain-gut-
microbiome (BGM) interactions with important implications for brain health, and for several …

Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal Transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Inflammation, lifestyle factors, and the microbiome‐gut‐brain Axis: relevance to depression and antidepressant action

F Donoso, JF Cryan… - Clinical …, 2023 - Wiley Online Library
Depression is considered a major public health concern, where existing pharmacological
treatments are not equally effective across all patients. The pathogenesis of depression …

Microbiota and sleep: awakening the gut feeling

P Sen, A Molinero-Perez, KJ O'Riordan… - Trends in molecular …, 2021 - cell.com
Various lifestyle and environmental factors are known to influence sleep. Increasingly,
evidence points to a role for the microbiota in regulating brain and behaviour. This article …

Shedding light on biological sex differences and microbiota–gut–brain axis: a comprehensive review of its roles in neuropsychiatric disorders

P Shobeiri, A Kalantari, AL Teixeira, N Rezaei - Biology of sex differences, 2022 - Springer
Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Feeding gut microbes to nourish the brain: Unravelling the diet–microbiota–gut–brain axis

E Schneider, KJ O'Riordan, G Clarke, JF Cryan - Nature metabolism, 2024 - nature.com
The prevalence of brain disorders, including stress-related neuropsychiatric disorders and
conditions with cognitive dysfunction, is rising. Poor dietary habits contribute substantially to …

The impact of the Mediterranean diet on alleviating depressive symptoms in adults: a systematic review and meta-analysis of randomized controlled trials

B Bizzozero-Peroni, V Martínez-Vizcaíno… - Nutrition …, 2025 - academic.oup.com
Context High adherence to the Mediterranean diet (MD) has been associated with a
reduced risk of depression in prospective cohort studies, but whether MD interventions are …

Roles and mechanisms of gut microbiota in patients with Alzheimer's disease

S Wu, X Liu, R Jiang, X Yan, Z Ling - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common age-related progressive neurodegenerative
disease, characterized by a decline in cognitive function and neuronal loss, and is caused …