Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Metagenomics, Metabolomics, and Metaproteomics have significantly advanced our
knowledge of microbial communities by providing culture-independent insights into their …

Transcortical vessels (TCVs) provide effective communication between bone marrow
vascular system and external circulation. Although osteocytes are in close contact with them …

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and
after extended liver resections, resulting in the inability to maintain or restore a sufficient …

The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic
steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown …

How to resolve the metabolic dark matter of microorganisms has long been a challenging
problem in discovering active molecules. Diverse omics tools have been developed to guide …

Chlorophyll is essential in photosynthesis, converting sunlight into chemical energy in
plants, algae, and certain bacteria. Its structure, featuring a porphyrin ring enclosing a …

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and
clinically heterogenous. The application of omics technologies—mainly studying nucleic …

Glycosphingolipids (GSLs) are essential components of cell membranes, particularly
enriched in the nervous system. Altered molecular distributions of GSLs are increasingly …

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical
confinement is a critical physical cue that induces switchable migration modes of the …