Strategies for the production of isotopically labelled Fab fragments of therapeutic antibodies in Komagataella phaffii (Pichia pastoris) and Escherichia coli for NMR …
D Gagné, M Sarker, G Gingras, DJ Hodgson, G Frahm… - Plos one, 2023 - journals.plos.org
The importance and fast growth of therapeutic monoclonal antibodies, both innovator and
biosimilar products, have triggered the need for the development of characterization …
biosimilar products, have triggered the need for the development of characterization …
Enabling site-specific NMR investigations of therapeutic Fab using a cell-free based isotopic labeling approach: application to anti-LAMP1 Fab
A Giraud, L Imbert, A Favier, F Henot, F Duffieux… - Journal of Biomolecular …, 2024 - Springer
Monoclonal antibodies (mAbs) are biotherapeutics that have achieved outstanding success
in treating many life-threatening and chronic diseases. The recognition of an antigen is …
in treating many life-threatening and chronic diseases. The recognition of an antigen is …
Backbone and methyl side-chain resonance assignments of the single chain Fab fragment of trastuzumab
D Gagné, JM Aramini, Y Aubin - Biomolecular NMR Assignments, 2024 - Springer
Trastuzumab is a therapeutic monoclonal antibody developed to target human epidermal
growth factor receptor 2 (HER2) present at higher levels in early cancers. Here we report the …
growth factor receptor 2 (HER2) present at higher levels in early cancers. Here we report the …
Backbone and methyl side-chain resonance assignments of the Fab fragment of adalimumab
M Sarker, Y Aubin - Biomolecular NMR Assignments, 2024 - Springer
Adalimumab is a therapeutic monoclonal antibody developed to target human TNF an
important mediator of immune-mediated inflammatory diseases such as rheumatoid arthritis …
important mediator of immune-mediated inflammatory diseases such as rheumatoid arthritis …