Osteoarthritis (OA) is one of the most common joint diseases currently, characterized by the
gradual degradation of cartilage, remodeling of subchondral bone, development of synovitis …

The carbohydrate hyaluronan (or hyaluronic acid, HA) is found in all human tissues and
biofluids where it has wide-ranging functions in health and disease that are dictated by both …

Severe acute inflammatory conditions may cause tissue damage, sepsis, and death. As a
critical component of the extracellular matrix, hyaluronic acid (HA) has been reported to …

The integral membrane protein CD44 is constitutively expressed in most tissues, and is the
primary cell surface receptor for hyaluronan (HA). HA is the key scaffolding organizer of …

At present, the occurrence and development of inflammatory diseases are closely related to
the abnormal changes of the content and function of many cytokines. At the same time …

Autoimmune thyroid diseases, such as Hashimoto's thyroiditis, are characterized by
lymphocytic infiltration and altered function of the thyroid. During inflammation, it has been …

Synovial fluid is composed of hyaluronan and proteoglycan-4 (PRG4 or lubricin), which work
synergistically to maintain joint lubrication. In diseases like osteoarthritis, hyaluronan and …

Previously synthesized N-butyrylated hyaluronic acid (BHA) provides anti-inflammatory
effects in rat models of acute gouty arthritis and hyperuricemia. However, the mechanism of …

Posttraumatic osteoarthritis (PTOA) can develop after an injury to the knee. Previous studies
have indicated that an intra‐articular (IA) injection of the potent glucocorticoid …

Inflammation plays a critical role in osteoarthritis (OA). It stimulates catabolic events in
articular chondrocytes and prevents chondrogenic precursor cells from repairing cartilage …