Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are
the leading cause of morbimortality in Western society. Both pathologies are frequently …

The first full publications on the biological effects of the diphosphonates, later renamed
bisphosphonates, appeared in 1969, so it is timely after 40 years to review the history of their …

Table of contents: I. Structure and function of joints, connective tissue, and muscle. II.
Immune and inflammatory responses. III. Evaluation of the patient. IV. Special issues of the …

The discovery and development of the bisphosphonates (BPs) as a major class of drugs for
the treatment of bone diseases has been a fascinating journey that is still not over. In clinical …

Bone is a dynamic tissue that is subject to the balanced processes of bone formation and
bone resorption. Imbalance can give rise to skeletal pathologies with increased bone …

The bisphosphonates (BPs) are well established as the treatments of choice for disorders of
excessive bone resorption, including Paget's disease of bone, myeloma and bone …

Three transcription factors of the Sox family have essential roles in different steps of the
chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is …

The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …

Highlights•Pyrophosphate prevents unwanted calcification making it the body's natural
'water-softener'.•The breakdown of ATP released from cells represents a key source of …

It is today acknowledged that aging is associated with a low-grade chronic inflammatory
status, and that inflammation exacerbates age-related diseases such as osteoporosis …