Macrophage polarization: different gene signatures in M1 (LPS+) vs. classically and M2 (LPS–) vs. alternatively activated macrophages
M Orecchioni, Y Ghosheh, AB Pramod… - Frontiers in …, 2019 - frontiersin.org
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …
macrophages are seeded in the early embryo before definitive hematopoiesis is …
[HTML][HTML] Beyond activation: characterizing microglial functional phenotypes
J Lier, WJ Streit, I Bechmann - Cells, 2021 - mdpi.com
Classically, the following three morphological states of microglia have been defined:
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …
ramified, amoeboid and phagocytic. While ramified cells were long regarded as “resting” …
A genome-scale screen for synthetic drivers of T cell proliferation
The engineering of autologous patient T cells for adoptive cell therapies has revolutionized
the treatment of several types of cancer. However, further improvements are needed to …
the treatment of several types of cancer. However, further improvements are needed to …
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
N Priego, L Zhu, C Monteiro, M Mulders… - Nature Medicine, 2018 - nature.com
The brain microenvironment imposes a particularly intense selective pressure on metastasis-
initiating cells, but successful metastases bypass this control through mechanisms that are …
initiating cells, but successful metastases bypass this control through mechanisms that are …
Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
among various subtypes. Here, we utilize single-cell RNA sequencing (scRNA-seq) to …
Evolving complexity of MIF signaling
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …
The immunobiology of MIF: function, genetics and prospects for precision medicine
I Kang, R Bucala - Nature Reviews Rheumatology, 2019 - nature.com
The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by
data showing that common functional polymorphisms in MIF are associated with disease …
data showing that common functional polymorphisms in MIF are associated with disease …
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …
[HTML][HTML] Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment
To define alterations early in tumor formation, we studied nerve tumors in neurofibromatosis
1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas …
1 (NF1), a tumor predisposition syndrome. Affected individuals develop neurofibromas …
Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: From pathogenic factors to therapeutic targets
S Günther, P Fagone, G Jalce, AG Atanasov… - Drug discovery today, 2019 - Elsevier
Highlights•MIF acts cytokine, enzyme, endocrine hormone and chaperon-like molecule.•D-
DT, a member of the MIF family, exerts non-redundant effects from MIF.•MIF and D-DT are up …
DT, a member of the MIF family, exerts non-redundant effects from MIF.•MIF and D-DT are up …