Therapeutic advances in COVID-19

N Murakami, R Hayden, T Hills, H Al-Samkari… - Nature Reviews …, 2023 - nature.com
Over 2 years have passed since the start of the COVID-19 pandemic, which has claimed
millions of lives. Unlike the early days of the pandemic, when management decisions were …

Antivirals with activity against mpox: a clinically oriented review

EA Siegrist, J Sassine - Clinical infectious diseases, 2023 - academic.oup.com
Mpox virus is an emergent human pathogen. While it is less lethal than smallpox, it can still
cause significant morbidity and mortality. In this review, we explore 3 antiviral agents with …

COVID-19 Survival and its impact on chronic kidney disease

JD Long, IAN Strohbehn, R Sawtell… - Translational …, 2022 - Elsevier
Up to 87% of patients hospitalized with coronavirus disease 2019 (COVID-19) experience
chronic sequelae following infection. The long-term impact of COVID-19 infection on kidney …

[HTML][HTML] Acute kidney injury associated with remdesivir: a comprehensive pharmacovigilance analysis of COVID-19 reports in FAERS

B Wu, M Luo, F Wu, Z He, Y Li, T Xu - Frontiers in Pharmacology, 2022 - frontiersin.org
Acute kidney injury (AKI) is a common complication among patients with the novel
coronavirus (COVID-19). COVID-19 along with AKI usually resulted in a poor prognosis for …

Clinical strategies and therapeutics for human monkeypox virus: a revised perspective on recent outbreaks

N Ghosh, L Chacko, J Vallamkondu, T Banerjee… - Viruses, 2023 - mdpi.com
An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative agent of the
zoonotic viral disease, human monkeypox (HMPX). MPXV belongs to the genus …

Consensus obtained for the nephrotoxic potential of 167 drugs in adult critically ill patients using a modified Delphi method

MP Gray, EF Barreto, DJ Schreier, JA Kellum, K Suh… - Drug Safety, 2022 - Springer
Introduction The approach to evaluating nephrotoxins in studies of drug-associated acute
kidney injury varies. Some studies use a list of under ten drugs for evaluation whereas …

Remdesivir versus standard-of-care for severe coronavirus disease 2019 infection: an analysis of 28-day mortality

SA Olender, TL Walunas, E Martinez… - Open forum …, 2021 - academic.oup.com
Background Remdesivir is approved by the US Food and Drug Administration for the
treatment of patients hospitalized with coronavirus disease 2019 (COVID-19) and has been …

Assessment of adverse events associated with remdesivir use for coronavirus disease 2019 using real-world data

A Singh, A Kamath - Expert Opinion on Drug Safety, 2021 - Taylor & Francis
Background: Remdesivir has been used for treating patients with moderate to severe
coronavirus disease 2019 (COVID-19) although there is conflicting evidence regarding its …

A propensity score–matched observational study of remdesivir in patients with COVID-19 and severe kidney disease

R Seethapathy, S Zhao, JD Long, IA Strohbehn… - Kidney360, 2022 - journals.lww.com
Background Remdesivir is not currently approved for patients with eGFR< 30 ml/min per
1.73 m 2. We aimed to determine the safety of remdesivir in patients with kidney failure …

Population pharmacokinetics of remdesivir and GS-441524 in hospitalized COVID-19 patients

E Leegwater, D Moes, LBE Bosma… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
The objective of this study was to describe the population pharmacokinetics of remdesivir
and GS-441524 in hospitalized coronavirus disease 2019 (COVID-19) patients. A …