HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022 - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

[HTML][HTML] Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies

R Bhattacharjee, SS Das, SS Biswal, A Nath… - Critical reviews in …, 2022 - Elsevier
Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …

The landscape of viral associations in human cancers

M Zapatka, I Borozan, DS Brewer, M Iskar… - Nature …, 2020 - nature.com
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …

Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer

M Petljak, AM Green, J Maciejowski, MD Weitzman - Nature genetics, 2022 - nature.com
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …

APOBEC: A molecular driver in cervical cancer pathogenesis

S Revathidevi, AK Murugan, H Nakaoka, I Inoue… - Cancer letters, 2021 - Elsevier
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

HPV16 and HPV18 genome structure, expression, and post-transcriptional regulation

L Yu, V Majerciak, ZM Zheng - International journal of molecular sciences, 2022 - mdpi.com
Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …

High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis

NSL Yeo-Teh, Y Ito, S Jha - International journal of molecular sciences, 2018 - mdpi.com
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …

Hallmarks of HPV carcinogenesis: The role of E6, E7 and E5 oncoproteins in cellular malignancy

D Estêvão, NR Costa, RMG da Costa… - Biochimica et Biophysica …, 2019 - Elsevier
Human papillomavirus (HPV) is the most common sexually transmitted infectious agent
worldwide, being also responsible for 5% of all human cancers. The integration and …

Footprint of the host restriction factors APOBEC3 on the genome of human viruses

F Poulain, N Lejeune, K Willemart, NA Gillet - PloS pathogens, 2020 - journals.plos.org
APOBEC3 enzymes are innate immune effectors that introduce mutations into viral
genomes. These enzymes are cytidine deaminases which transform cytosine into uracil …

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix …

C Guo, X Qu, X Tang, Y Song, J Wang… - Clinical and …, 2023 - Wiley Online Library
Background The mechanism underlying cervical carcinogenesis that is mediated by
persistent human papillomavirus (HPV) infection remains elusive. Aims Here, for the first …