Fibronectin type III domain-based fusion proteins
Provided herein are fusion proteins including at least one binding polypeptide and at least
one unstructured polypeptide. The fusion protein may further include at least one linker …
one unstructured polypeptide. The fusion protein may further include at least one linker …
Phase transition biopolymers and methods of use
US9771396B2 - Phase transition biopolymers and methods of use - Google Patents
US9771396B2 - Phase transition biopolymers and methods of use - Google Patents Phase …
US9771396B2 - Phase transition biopolymers and methods of use - Google Patents Phase …
Phase transition biopolymers and methods of use
A Chilkoti, FG Quiroz - US Patent 8,912,310, 2014 - Google Patents
The present disclosure describes environmentally responsive polypeptides capable of
displaying stimuli-triggered confor mational changes in a reversible or irreversible manner …
displaying stimuli-triggered confor mational changes in a reversible or irreversible manner …
Order and disorder as a design principle for stimuli-responsive biopolymer networks
A Chilkoti, S Roberts - US Patent 11,680,083, 2023 - Google Patents
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O [C@@ H] 1 [C@@
H](O)[C@ H](O)[C@@ H](CN) O [C@@ H] 1O [C@ H] 1 [C@ H](O)[C@@ H](O [C@@ H] 2 …
H](O)[C@ H](O)[C@@ H](CN) O [C@@ H] 1O [C@ H] 1 [C@ H](O)[C@@ H](O [C@@ H] 2 …
Polymer conjugates having reduced antigenicity and methods of using the same
A Chilkoti, Y Qi, MS Hershfield, NJ Ganson - US Patent 10,364,451, 2019 - Google Patents
Disclosed herein are compositions and methods for reducing the antigenicity of molecules.
The antigenicity of a molecule may be reduced or eliminated by conjugating at least one …
The antigenicity of a molecule may be reduced or eliminated by conjugating at least one …
具有lcst 行为的非结构化无重复多肽
阿舒托什, 奇尔科提, 尼古拉斯, 加雷特, 凯利 - 2019 - Google Patents
A61K47/50—Medicinal preparations characterised by the non-active ingredients used, eg
carriers or inert additives; Targeting or modifying agents chemically bound to the active …
carriers or inert additives; Targeting or modifying agents chemically bound to the active …
Amphiphilic polynucleotides
A Chilkoti, S Zauscher, L Tang… - US Patent 11,965,164, 2024 - Google Patents
Compositions and methods disclosed herein can help provide improved delivery of non-
natural therapeutic nucleotides for the treatment of diseases such as cancer. An example …
natural therapeutic nucleotides for the treatment of diseases such as cancer. An example …
Genetically encoded polypeptide for affinity capture and purification of biologics
KM Luginbuhl, A Chilkoti - US Patent App. 18/346,456, 2024 - Google Patents
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O [C@@ H] 1 [C@@
H](O)[C@ H](O)[C@@ H](CN) O [C@@ H] 1O [C@ H] 1 [C@ H](O)[C@@ H](O [C@@ H] 2 …
H](O)[C@ H](O)[C@@ H](CN) O [C@@ H] 1O [C@ H] 1 [C@ H](O)[C@@ H](O [C@@ H] 2 …
Immune Tolerant Elastin-Like Peptide Tetramer Guided Nanoparticles And Methods Of Use
M Chen, P Zhao - US Patent App. 17/549,367, 2022 - Google Patents
BACKGROUND [0003] Cancer immune checkpoint therapy has achieved remarkable
clinical successes in various cancers. Current immune checkpoint inhibitors, however, block …
clinical successes in various cancers. Current immune checkpoint inhibitors, however, block …
Unstructured non-repetitive polypeptides having lcst behavior
A Chilkoti, T Nicholas, G Kelly - US Patent 12,084,480, 2024 - Google Patents
Described herein are unstructured polypeptides lacking any discernible repeat motif. Also
described herein are fusion proteins including at least one of the unstructured polypeptides …
described herein are fusion proteins including at least one of the unstructured polypeptides …