[HTML][HTML] Chemoresistance in breast cancer: PI3K/Akt pathway inhibitors vs the current chemotherapy

PJ Kaboli, S Imani, M Jomhori… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Breast cancer is the most prevalent type of cancer among women. Several types of drugs,
targeting the specific proteins expressed on the breast cancer cell surface (such as receptor …

Advances of targeted therapy for hepatocellular carcinoma

M Niu, M Yi, N Li, K Wu, K Wu - Frontiers in Oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the common and fatal malignancies, which is a
significant global health problem. The clinical applicability of traditional surgery and other …

ST6GAL1 is a novel serum biomarker for lenvatinib-susceptible FGF19-driven hepatocellular carcinoma

Y Myojin, T Kodama, K Maesaka, D Motooka… - Clinical Cancer …, 2021 - AACR
Purpose: Hepatocellular carcinoma (HCC) is characterized by high intertumor heterogeneity
of genetic drivers. Two multitarget tyrosine kinase inhibitors (TKI), lenvatinib and sorafenib …

Identification of MX2 as a novel prognostic biomarker for sunitinib resistance in clear cell renal cell carcinoma

Y Wei, X Chen, X Ren, B Wang, Q Zhang, H Bu… - Frontiers in …, 2021 - frontiersin.org
Background Antiangiogenic agents that specifically target vascular endothelial growth factor
receptor (VEGFR), such as sunitinib, have been utilized as the standard therapy for …

mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway

SJ Xie, LT Diao, N Cai, LT Zhang, S Xiang, CC Jia… - Cell death …, 2021 - nature.com
MALAT1-associated small cytoplasmic RNA (mascRNA) is a cytoplasmic tRNA-like small
RNA derived from nucleus-located long noncoding RNA (lncRNA) metastasis-associated …

Polyphenol-enriched Penthorum chinense Pursh ameliorates alcohol-related liver injury through Ras/Raf/MEK/ERK pathway: Integrating network pharmacology and …

R Li, D Wu, J Hu, Y Ma, Y Ba, L Zou, Y Hu - Journal of Ethnopharmacology, 2024 - Elsevier
Abstract Ethnopharmacological relevance Penthorum chinense Pursh (PCP) has
acknowledged as an edible herbal medicinal plant for the prevention and treatment of …

Lifetime impact of cow's milk on overactivation of mTORC1: From fetal to childhood overgrowth, acne, diabetes, cancers, and neurodegeneration

BC Melnik - Biomolecules, 2021 - mdpi.com
The consumption of cow's milk is a part of the basic nutritional habits of Western
industrialized countries. Recent epidemiological studies associate the intake of cow's milk …

MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of HIF-1α and ANGPT2

YH Huang, WS Lian, FS Wang, PW Wang… - International Journal of …, 2022 - mdpi.com
A high-fat diet is responsible for hepatic fat accumulation that sustains chronic liver damage
and increases the risks of steatosis and hepatocellular carcinoma (HCC). MicroRNA-29a …

A combined network pharmacology and molecular biology approach to investigate the active ingredients and potential mechanisms of mulberry (Morus alba L.) leaf on …

R Li, C Wang, Y Chen, N Li, Q Wang, M Zhang, C He… - Phytomedicine, 2021 - Elsevier
Background As one of traditional Chinese medicine, mulberry leaf is abundant in diverse
active ingredients and widely used for the treatment of metabolic disease and its …

[HTML][HTML] Albumin nanoparticles and their folate modified counterparts for delivery of a lupine derivative to hepatocellular carcinoma

H Wang, D Wu, P Wang, C Gao, H Teng, D Liu… - Biomedicine & …, 2023 - Elsevier
In this study, folate polyethylene glycol CTr albumin nanoparticles (FA-PEG-CTr-NPs)
targeting hepatocellular carcinoma (HCC) were prepared. The nanoparticle preparation …