Structure, assembly, and function of tripartite efflux and type 1 secretion systems in gram-negative bacteria
Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …
organisms are diverse in function, energization, and structural organization. They form …
Structural and functional diversity of resistance–nodulation–cell division transporters
PA Klenotic, MA Moseng, CE Morgan, EW Yu - Chemical reviews, 2020 - ACS Publications
Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …
becoming increasingly difficult to eliminate. While significant effort has gone into the …
Bacterial multidrug efflux transporters
Infections caused by bacteria are a leading cause of death worldwide. Although antibiotics
remain a key clinical therapy, their effectiveness has been severely compromised by the …
remain a key clinical therapy, their effectiveness has been severely compromised by the …
[图书][B] Chemistry of antibiotics and related drugs
MK Bhattacharjee - 2016 - Springer
Millions of lives have been saved by antibiotics since they were first discovered more than
90 years ago. This book discusses the various classes of antibiotics and their mechanisms …
90 years ago. This book discusses the various classes of antibiotics and their mechanisms …
[HTML][HTML] Assembly and channel opening in a bacterial drug efflux machine
Drugs and certain proteins are transported across the membranes of Gram-negative
bacteria by energy-activated pumps. The outer membrane component of these pumps is a …
bacteria by energy-activated pumps. The outer membrane component of these pumps is a …
[HTML][HTML] The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components
JW Handing, SA Ragland, UV Bharathan… - Frontiers in …, 2018 - frontiersin.org
The mucosal inflammatory response to Neisseria gonorrhoeae (Gc) is characterized by
recruitment of neutrophils to the site of infection. Gc survives exposure to neutrophils by …
recruitment of neutrophils to the site of infection. Gc survives exposure to neutrophils by …
Structural basis of peptide-based antimicrobial inhibition of a resistance-nodulation-cell division multidrug efflux pump
Bacterial efflux pumps in the resistance-nodulation-cell division (RND) family of Gram-
negative bacteria contribute significantly to the development of antimicrobial resistance by …
negative bacteria contribute significantly to the development of antimicrobial resistance by …
[HTML][HTML] MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA
HT Lin, VN Bavro, NP Barrera, HM Frankish… - Journal of biological …, 2009 - ASBMB
Gram-negative bacteria utilize specialized machinery to translocate drugs and protein toxins
across the inner and outer membranes, consisting of a tripartite complex composed of an …
across the inner and outer membranes, consisting of a tripartite complex composed of an …
[HTML][HTML] Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies
Recent years have seen major advances in the structural understanding of the different
components of tripartite efflux assemblies, which encompass the multidrug efflux (MDR) …
components of tripartite efflux assemblies, which encompass the multidrug efflux (MDR) …
The A bg T family: a novel class of antimetabolite transporters
JA Delmar, EW Yu - Protein Science, 2016 - Wiley Online Library
The AbgT family of transporters was thought to contribute to bacterial folate biosynthesis by
importing the catabolite p‐aminobenzoyl‐glutamate for producing this essential vitamin …
importing the catabolite p‐aminobenzoyl‐glutamate for producing this essential vitamin …