In the 1990s and early 2000s, the common definition for sarcopenia was age-related loss of
skeletal muscle, and low levels of muscle mass were central to sarcopenia diagnosis. In …

Background: This article discusses the putative neural mechanisms of age-related muscle
weakness within the broader context of the development of function-promoting therapies for …

Introduction Certain genes increase the risk of age-related neurological dysfunction and/or
disease. For instance, ApoE is a well-known gene carrying risk for Alzheimer's disease …

Background People≥ 65 years are expected to live a substantial portion of their remaining
lives with a limiting physical condition and the numbers of affected individuals will increase …

Macromolecules damaged by covalent modifications produced by chemically reactive
metabolites accumulate in the slowly renewable components of living bodies and …

Background Older adults display wide individual variability (heterogeneity) in the effects of
resistance exercise training on muscle strength. The mechanisms driving this heterogeneity …

Background Fatigability in community-dwelling older adults is highly prevalent and
disabling, but lacks a treatment. Greater nigrostriatal dopaminergic signaling can ameliorate …

There is increasing appreciation of the role of rate of torque development (RTD) in physical
function of older adults (OAs). This study compared various RTD strategies and …

Background: Fatigability in community-dwelling older adults is highly prevalent and
disabling, but lacks a treatment. Greater nigrostriatal dopaminergic signaling can ameliorate …

Abstract Background and Objective: Serotonin and dopamine are monoamine
neurotransmitters that are effective in mood and happiness, which are reduced in old age …