Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

Abstract Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but
has limited efficacy against pulmonary TB disease development and modest protection …

Development of idiosyncratic hepatotoxicity is an intricate process involving both concurrent
as well as sequential events determining the direction of the pathways, degree of liver injury …

The cornerstone of tuberculosis management is a 6‐month course of isoniazid, rifampicin,
pyrazinamide and ethambutol. Compliance is crucial for curing tuberculosis. Adverse effects …

Liver plays a central role in the metabolism and excretion of xenobiotics which makes it
highly susceptible to their adverse and toxic effects. Liver injury caused by various toxic …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Rutin, a well-known flavonoid was investigated for its possible protective effect against
paracetamol-and CCl4-induced hepatic damage. Paracetamol produced 100% mortality at …

BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …

BACKGROUND/AIMS: To evaluate the role of mitochondrial oxidative stress and
permeability transition (MPT) in isoniazid (INH) and rifampicin (RMP) induced hepatotoxicity …

Hepatotoxicity induced by antituberculosis drugs is a serious adverse reaction with
significant morbidity and even, rarely, mortality. This form of toxicity potentially impacts the …