Medicinal mushrooms have been used for centuries as nutraceuticals to improve health and
to treat numerous chronic and infectious diseases. One such mushroom is Ganoderma …

Historically, targeting protein–protein interactions with small molecules was not thought
possible because the corresponding interfaces were considered mostly flat and featureless …

The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with
two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are …

Mushrooms are known not only for their taste but also for beneficial effects on health
attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which …

Trisomy of human chromosome 21 (HSA21) causes Down syndrome (DS). The trisomy does
not simply result in the upregulation of HSA21--encoded genes but also leads to a genome …

We selected edible and inedible mushrooms growing in the Mediterranean area of France to
screen their biological activity: Caloboletus calopus, Rubroboletus lupinus, R …

The mechanisms of action of natural products and the identification of their targets have long
been a research hotspot. Ganoderic acid A (GAA) is the earliest and most abundant …

Basidiomycetes, a major class of higher fungi adapted to many different climates, habitats,
and substrates, have developed a rich and very diverse secondary metabolism. Its products …

The ubiquitin–proteasome system (UPS) is the major non-lysosomal pathway responsible
for regulated degradation of intracellular proteins in eukaryotes. As the principal proteolytic …

In response to foreign or endogenous stimuli, both microglia and astrocytes adopt an
activated phenotype that promotes the release of pro-inflammatory mediators. This …