JARID1 histone demethylases: emerging targets in cancer
KM Harmeyer, ND Facompre, M Herlyn, D Basu - Trends in cancer, 2017 - cell.com
JARID1 proteins are histone demethylases that both regulate normal cell fates during
development and contribute to the epigenetic plasticity that underlies malignant …
development and contribute to the epigenetic plasticity that underlies malignant …
Diverse functions of KDM5 in cancer: Transcriptional repressor or activator?
Y Ohguchi, H Ohguchi - Cancers, 2022 - mdpi.com
Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3
M Albert, SU Schmitz, SM Kooistra, M Malatesta… - PLoS …, 2013 - journals.plos.org
Embryonic development is tightly regulated by transcription factors and chromatin-
associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with …
associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with …
The embryonic linker histone H1 variant of Drosophila, dBigH1, regulates zygotic genome activation
S Pérez-Montero, A Carbonell, T Morán, A Vaquero… - Developmental cell, 2013 - cell.com
Histone H1 is an essential chromatin component. Metazoans usually contain multiple stage-
specific H1s. In particular, specific variants replace somatic H1s during early …
specific H1s. In particular, specific variants replace somatic H1s during early …
The histone demethylase KDM5 activates gene expression by recognizing chromatin context through its PHD reader motif
KDM5 family proteins are critically important transcriptional regulators whose physiological
functions in the context of a whole animal remain largely unknown. Using genome-wide …
functions in the context of a whole animal remain largely unknown. Using genome-wide …
Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling
Oocytes are arrested for long periods of time in the prophase of the first meiotic division
(prophase I). As chromosome condensation poses significant constraints to gene …
(prophase I). As chromosome condensation poses significant constraints to gene …
Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex
G Nishibuchi, Y Shibata, T Hayakawa… - Journal of Biological …, 2014 - ASBMB
Histone H3K4 methylation has been linked to transcriptional activation. KDM5A (also known
as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4 demethylase …
as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4 demethylase …
Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes‐Jensen syndrome
The widespread availability of genetic testing for those with neurodevelopmental disorders
has highlighted the importance of many genes necessary for the proper development and …
has highlighted the importance of many genes necessary for the proper development and …
Lysine demethylase 5A Is required for MYC-driven transcription in multiple myeloma
Abstract Lysine demethylase 5A (KDM5A) is a negative regulator of histone H3 lysine 4
trimethylation (H3K4me3), a histone mark associated with activate gene transcription. We …
trimethylation (H3K4me3), a histone mark associated with activate gene transcription. We …
Ibf1 and I bf2 are novel CP 190‐interacting proteins required for insulator function
Insulators are DNA‐protein complexes that play a central role in chromatin organization and
regulation of gene expression. In D rosophila different proteins, d CTCF, S u (H w), and …
regulation of gene expression. In D rosophila different proteins, d CTCF, S u (H w), and …