The molecular basis of herpes simplex virus latency

MP Nicoll, JT Proença… - FEMS microbiology …, 2012 - academic.oup.com
Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within
sensory neurones. Following primary infection, the virus replicates productively within …

A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation

PGE Kennedy, J Rovnak… - Journal of General …, 2015 - microbiologyresearch.org
Herpes simplex virus type 1 (HSV-1; human herpesvirus 1) and varicella-zoster virus (VZV;
human herpesvirus 3) are human neurotropic alphaherpesviruses that cause lifelong …

[HTML][HTML] Strength in diversity: Understanding the pathways to herpes simplex virus reactivation

JB Suzich, AR Cliffe - Virology, 2018 - Elsevier
Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can
periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli …

The role of microRNAs in the pathogenesis of herpesvirus infection

D Piedade, JM Azevedo-Pereira - Viruses, 2016 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs important in gene regulation. They are
able to regulate mRNA translation through base-pair complementarity. Cellular miRNAs …

A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency

D Pan, O Flores, JL Umbach, JM Pesola, P Bentley… - Cell host & …, 2014 - cell.com
After infecting peripheral sites, herpes simplex virus (HSV) invades the nervous system and
initiates latent infection in sensory neurons. Establishment and maintenance of HSV latency …

Herpesviral latency—common themes

M Weidner-Glunde, E Kruminis-Kaszkiel… - Pathogens, 2020 - mdpi.com
Latency establishment is the hallmark feature of herpesviruses, a group of viruses, of which
nine are known to infect humans. They have co-evolved alongside their hosts, and mastered …

[HTML][HTML] Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity

DM Knipe - Virology, 2015 - Elsevier
Herpes simplex virus (HSV) undergoes a lytic infection in epithelial cells and a latent
infection in neuronal cells, and epigenetic mechanisms play a major role in the differential …

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

SZ Bahojb Mahdavi, A Jebelli… - Medicinal Research …, 2024 - Wiley Online Library
Infections caused by viruses as the smallest infectious agents, pose a major threat to global
public health. Viral infections utilize different host mechanisms to facilitate their own …

Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional response

JZ Ma, TA Russell, T Spelman, FR Carbone… - PLoS …, 2014 - journals.plos.org
Herpes simplex viruses (HSV) are significant human pathogens that provide one of the best-
described examples of viral latency and reactivation. HSV latency occurs in sensory …

MicroRNAs: Harbingers and shapers of periodontal inflammation

X Luan, X Zhou, P Fallah, M Pandya, H Lyu… - Seminars in cell & …, 2022 - Elsevier
Periodontal disease is an inflammatory reaction of the periodontal tissues to oral pathogens.
In the present review we discuss the intricate effects of a regulatory network of gene …