Objectives To conduct a systematic literature review and meta-analysis to estimate the
proportion of fever of unknown origin (FUO) and inflammation of unknown origin (IUO) cases …

The clinical yield and benefit of performing bone marrow cultures for various clinical
indications has been challenged and their clinical necessity remains debatable. We sought …

INTRODUCTION—Clinicians commonly refer to a febrile illness without an initially obvious
etiology (sometimes called fever without localizing signs) as fever of unknown origin (FUO) …

Background Bone marrow biopsy (BMB) is an accepted investigation in fever of unknown
origin (FUO) to uncover haematological malignancies, such as lymphoma, and sometimes …

Primary bone marrow lymphoma (PBML) represents non‐Hodgkin lymphoma (NHL) that
primarily arises in the bone marrow (BM) without lymphadenopathy. This condition has …

The diagnosis and treatment of fever of unknown origin (FUO) are huge challenges to
clinicians. Separating the etiologies of FUO into infectious and non-infectious disease is …

The diagnosis of hemophagocytic lymphohistiocytosis (HLH) is delayed by most physicians.
This study aimed to identify early parameters and suitable scoring systems for the risk of …

The criteria for primary bone marrow large B-cell lymphoma (PBMLBCL) have not yet been
clearly established. We aimed to investigate the clinicopathological features of PBMLBCLs …

Background Trephine bone marrow biopsy (BMB) in internal medicine has only been
studied in fever of unknown origin and inflammation of unknown origin. The aim was to …

A stepwise approach is essential to evaluating pyrexia of unknown origin (PUO). When other
investigations are negative, bone marrow examination is a valuable diagnostic tool in PUO …