Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate
immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Rotaviruses cause life-threatening gastroenteritis in children worldwide; the enormous
disease burden has focused efforts to develop vaccines and led to the discovery of novel …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …

The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist
which could complement growth of influenza delNS1 virus, a mutant influenza virus lacking …

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in
mammals. Although this family was originally identified in the context of the type I interferon …

In the course of combating infectious agents, type I interferon (IFN) needs a timely
downregulation mechanism to avoid detrimental overreaction. Here we showed a …

IFN regulatory factor 3 (IRF3), a constitutively expressed protein localizing largely to the
cytoplasm, is a primary effector of the innate immune response. Infection can trigger the …

Secretion of interferon (IFN) by virus-infected cells is essential for activating autocrine and
paracrine pathways that promote cellular transition to an antiviral state. In most mammalian …