Autonomic manifestations of epilepsy: emerging pathways to sudden death?

RD Thijs, P Ryvlin, R Surges - Nature Reviews Neurology, 2021 - nature.com
Epileptic networks are intimately connected with the autonomic nervous system, as
exemplified by a plethora of ictal (during a seizure) autonomic manifestations, including …

Drug‐resistant epilepsy and mortality—Why and when do neuromodulation and epilepsy surgery reduce overall mortality

S Rheims, MR Sperling, P Ryvlin - Epilepsia, 2022 - Wiley Online Library
Patients with drug‐resistant epilepsy have an increased mortality rate, with the majority of
deaths being epilepsy related and 40% due to sudden unexpected death in epilepsy …

Abnormal static and dynamic functional network connectivity of the whole-brain in children with generalized tonic-clonic seizures

Y Li, Y Ran, Q Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Generalized tonic-clonic seizures (GTCS) are a subtype of generalized seizures
exhibiting bursts of bilaterally synchronous generalized spike-wave discharges. Numerous …

Neuropathology findings in autonomic brain regions in SUDEP and future research directions

S Patodia, A Somani, M Thom - Autonomic Neuroscience, 2021 - Elsevier
Autonomic dysfunction is implicated from clinical, neuroimaging and experimental studies in
sudden and unexpected death in epilepsy (SUDEP). Neuropathological analysis in SUDEP …

Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea

C Zeicu, A Legouhy, CA Scott, JFA Oliveira… - …, 2023 - Wiley Online Library
Objectives Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death for
patients with epilepsy; however, the pathophysiology remains unclear. Focal‐to‐bilateral …

Sudden unexpected death in epilepsy

D Friedman - Current Opinion in Neurology, 2022 - journals.lww.com
Sudden unexpected death in epilepsy : Current Opinion in Neurology Sudden unexpected
death in epilepsy : Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe …

Peri‐ictal and non‐seizure EEG event detection using generated metadata

P Handa, N Goel - Expert Systems, 2022 - Wiley Online Library
Lack of open access, seizure specific database has hindered the development of Automated
Seizure Detection System (ASDS) along with state‐of‐the‐art feature selection and …

Volumetric and microstructural abnormalities of the amygdala in focal epilepsy with varied levels of SUDEP risk

A Legouhy, LA Allen, SB Vos, JFA Oliveira… - Epilepsy Research, 2023 - Elsevier
Although the mechanisms of sudden unexpected death in epilepsy (SUDEP) are not yet well
understood, generalised-or focal-to-bilateral tonic-clonic seizures (TCS) are a major risk …

Regional microglial populations in central autonomic brain regions in SUDEP

A Somani, H El‐Hachami, S Patodia, S Sisodiya… - …, 2021 - Wiley Online Library
Objective Sudden unexpected death in epilepsy (SUDEP) may arise as a result of
autonomic dysfunction during a seizure. The central autonomic networks (CANs) modulate …

Cortical neuronal hypertrophy and mTOR pathway activation in CAN regions in SUDEP

S Patodia, YM Lim, F Chung, I Stylianou… - …, 2022 - Wiley Online Library
Objectives Dysfunctional connectivity and preexisting structural abnormalities of central
autonomic network (CAN) regions have been shown on magnetic resonance imaging (MRI) …