Investigations into the mixed muscle–secretory phenotype of cardiomyocytes from the atrial
appendages of the heart led to the discovery that these cells produce, in a regulated …

Evolutionary change in animal morphology results from alteration of the functional
organization of the gene regulatory networks (GRNs) that control development of the body …

Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the
difficulties in modeling this complex organ currently by in vitro models. Here we develop a …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

TBX5 is a member of the T-box transcription factor family and is primarily known for its role in
cardiac and forelimb development. Human patients with dominant mutations in TBX5 are …

The myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized …

The discovery of the first heart field (FHF) and the second heart field (SHF) led us to
understand how cardiac lineages and structures arise during development. However, it …

Congenital heart diseases often involve maldevelopment of the evolutionarily recent right
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …

Gene-regulatory enhancers have been identified using various approaches, including
evolutionary conservation, regulatory protein binding, chromatin modifications, and DNA …