Levosimendan in pulmonary hypertension and right heart failure

MS Hansen, A Andersen… - Pulmonary …, 2018 - journals.sagepub.com
Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right
ventricular function is the most important predictor of morbidity and mortality in patients …

Acute decompensated pulmonary hypertension

L Savale, J Weatherald, X Jaïs… - European …, 2017 - Eur Respiratory Soc
Acute right heart failure in chronic precapillary pulmonary hypertension is characterised by a
rapidly progressive syndrome with systemic congestion resulting from impaired right …

[HTML][HTML] Treatment of right ventricular dysfunction and heart failure in pulmonary arterial hypertension

C Inampudi, RJ Tedford, AR Hemnes… - Cardiovascular …, 2020 - ncbi.nlm.nih.gov
Right heart dysfunction and failure is the principal determinant of adverse outcomes in
patients with pulmonary arterial hypertension (PAH). In addition to right ventricular (RV) …

Use of levosimendan in patients with pulmonary hypertension: what is the current evidence?

D Masarone, M Kittleson, P Pollesello, RJ Tedford… - Drugs, 2023 - Springer
Pulmonary hypertension, defined as an increase in mean arterial pressure> 20 mmHg, is a
chronic and progressive condition with high mortality and morbidity. Drug therapy of patients …

The effect of levosimendan on the right ventricular function in patients with right ventricular dysfunction undergoing mitral valve surgery

KS Bharathi, G Pruthi, M Dhananjaya… - Annals of Cardiac …, 2023 - journals.lww.com
Background: Right ventricular (RV) dysfunction is an important predictor of both immediate
and long-term outcomes in valve surgeries. Levosimendan has proven beneficial in …

Pressure overload and right ventricular failure: from pathophysiology to treatment

N Dayer, Z Ltaief, L Liaudet, B Lechartier… - Journal of Clinical …, 2023 - mdpi.com
Right ventricular failure (RVF) is often caused by increased afterload and disrupted coupling
between the right ventricle (RV) and the pulmonary arteries (PAs). After a phase of adaptive …

Effect of levosimendan on acute decompensated right heart failure in patients with connective tissue disease-associated pulmonary arterial hypertension

C Qu, W Feng, Q Zhao, Q Liu, X Luo, G Wang… - Frontiers in …, 2022 - frontiersin.org
Aims Acute decompensated right heart failure (RHF) in chronic precapillary pulmonary
hypertension is often typified by a swiftly progressive syndrome involving systemic …

Levosimendan, milrinone, and dobutamine in experimental acute pulmonary embolism

MD Lyhne, SJ Dragsbaek, JV Hansen… - Pulmonary …, 2021 - journals.sagepub.com
Acute pulmonary embolism is a frequent condition in emergency medicine and potentially
fatal. Cause of death is right ventricular failure due to increased right ventricular afterload …

Excitation-contraction coupling and relaxation alteration in right ventricular remodelling caused by pulmonary arterial hypertension

F Antigny, O Mercier, M Humbert, J Sabourin - Archives of cardiovascular …, 2020 - Elsevier
Pulmonary arterial hypertension is a progressive and lethal cardiopulmonary disease. The
rise in right ventricular afterload leads to right ventricular hypertrophy and failure. Right …

Efficacy and safety of a calcium sensitizer, levosimendan, in patients with right heart failure due to pulmonary hypertension

R Jiang, QH Zhao, WH Wu, R Zhang… - The clinical …, 2018 - Wiley Online Library
Background Despite using vasoactive and pulmonary hypertension (PH) specific therapies,
the in‐hospital mortality of severe PH with right heart failure (RHF) is high. We conducted a …