RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …

mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs)
that determine mRNA fate, thereby influencing multiple cellular functions across biological …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under
conditions of cellular stress. Promotion of stress granule formation by TIA-1 depends upon …

Innate immune response is triggered by pathogen components, like lipopolysaccharides
(LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which …

Viral RNA-host protein interactions are indispensable during RNA virus transcription and
replication, but their detailed structural and dynamical features remain largely elusive. Here …

Ribonucleoprotein complexes (RNPs) are central to all processes in the cell. One of the
prerequisites to understand how RNPs work is to determine their high-resolution structures …

ABSTRACT TDP-43 (also known as TARDBP) is a nuclear splicing factor functioning in pre-
mRNA processing. Its C-terminal 35-kDa fragment (TDP-35) forms inclusions or aggregates …

Stress granules are non-membrane bound RNA-protein granules essential for survival
during acute cellular stress. TIA-1 is a key protein in the formation of stress granules that …