The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the
specificity of these pathways is not well understood. This study examined whether the …

Glioblastoma is a highly aggressive brain tumor that is characterized by its unparalleled
invasiveness. Invasive glioblastoma cells not only escape surgery and focal therapies but …

CK2 is a highly conserved tetrameric serine/threonine kinase present in all eukaryotic
organisms. It is constitutively active, and appears to be regulated by level of expression and …

Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization
and endocytosis. However, it is now clear that they scaffold many intracellular signaling …

Protease-activated receptor-1 (PAR1) is a guanine nucleotide-binding (G) protein-coupled
receptor that elicits cellular responses to coagulant and anticoagulant proteases. Activation …

The cnidarian freshwater polyp Hydra sp. exhibits an unparalleled regeneration capacity in
the animal kingdom. Using an integrative transcriptomic and stable isotope labeling by …

Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …

Dishevelled (Dvl) is a key component in the Wnt/β-catenin signaling pathway. Dvl can
multimerize to form dynamic protein aggregates, which are required for the activation of …