Hydrogels in spinal cord injury repair strategies

G Perale, F Rossi, E Sundstrom… - ACS chemical …, 2011 - ACS Publications
Nowadays there are at present no efficient therapies for spinal cord injury (SCI), and new
approaches have to be proposed. Recently, a new regenerative medicine strategy has been …

Application of cell encapsulation for controlled delivery of biological therapeutics

G Orive, E Santos, JL Pedraz, RM Hernández - Advanced drug delivery …, 2014 - Elsevier
Cell microencapsulation technology is likely to have an increasingly important role in new
approaches rather than the classical and pioneering organ replacement. Apart from …

Engineering neural stem cell fates with hydrogel design for central nervous system regeneration

X Li, E Katsanevakis, X Liu, N Zhang, X Wen - Progress in polymer science, 2012 - Elsevier
Injuries and disease to the central nervous system (CNS) are accompanied by severe
consequences, as the adult CNS has very limited capacity to replace the lost neural cells …

Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration

V Veneruso, F Rossi, A Villella, A Bena… - Journal of Controlled …, 2019 - Elsevier
Spinal cord injury (SCI) is a complicated neuropathological condition that results in
functional dysfunction and paralysis. Various treatments have been proposed including …

Regeneration of rat sciatic nerve using PLGA conduit containing rat ADSCs with controlled release of BDNF and gold nanoparticles

M Jahromi, S Razavi, R Seyedebrahimi, P Reisi… - Journal of Molecular …, 2021 - Springer
Implantation of a nerve guidance conduit (NGC) carrying neuroprotective factors is
promising for repairing peripheral nerve injury. Here, we developed a novel strategy for …

Delivery of alginate scaffold releasing two trophic factors for spinal cord injury repair

I Grulova, L Slovinska, J Blaško, S Devaux… - Scientific reports, 2015 - nature.com
Spinal cord injury (SCI) has been implicated in neural cell loss and consequently functional
motor and sensory impairment. In this study, we propose an alginate-based neurobridge …

Mesh size distribution determination of interpenetrating polymer network hydrogels

L Pescosolido, L Feruglio, R Farra, S Fiorentino… - Soft Matter, 2012 - pubs.rsc.org
The importance of Interpenetrating Polymer Networks (IPNs) in biomedical and
pharmaceutical fields is continuously growing because of their mechanical and drug carrier …

Approaches for neural tissue regeneration

L Binan, A Ajji, G De Crescenzo, M Jolicoeur - Stem Cell Reviews and …, 2014 - Springer
There is currently no treatment for neurodegenerative diseases such as Parkinson's or
Alzheimer's diseases. While spinal cord injury has no treatment either, nerve injuries are …

Droplet-based microfluidics: an efficient high-throughput portable system for cell encapsulation

H Dortaj, AM Amani, L Tayebi, N Azarpira… - Journal of …, 2024 - Taylor & Francis
One of the goals of tissue engineering and regenerative medicine is restoring primary living
tissue function by manufacturing a 3D microenvironment. One of the main challenges is …

Using polymeric materials to control stem cell behavior for tissue regeneration

N Zhang, DH Kohn - Birth Defects Research Part C: Embryo …, 2012 - Wiley Online Library
Patients with organ failure often suffer from increased morbidity and decreased quality of life.
Current strategies of treating organ failure have limitations, including shortage of donor …