Phytocannabinoids and schizophrenia: Focus on adolescence as a critical window of enhanced vulnerability and opportunity for treatment

T Stark, S Di Martino, F Drago, CT Wotjak… - Pharmacological …, 2021 - Elsevier
The recent shift in socio-political debates and growing liberalization of Cannabis use across
the globe has raised concern regarding its impact on vulnerable populations such as …

Is cannabidiol during neurodevelopment a promising therapy for schizophrenia and autism spectrum disorders?

CM Loss, L Teodoro, GD Rodrigues… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental
disorders that cause high levels of functional disabilities. Also, the currently available …

Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation …

TA Lesh, AM Iosif, C Tanase, RM Vlasova… - Molecular …, 2023 - nature.com
Maternal infection has emerged as an important environmental risk factor for
neurodevelopmental disorders, including schizophrenia and autism spectrum disorders …

Maternal immune activation during pregnancy alters postnatal brain growth and cognitive development in nonhuman primate offspring

RM Vlasova, AM Iosif, AM Ryan, LH Funk… - Journal of …, 2021 - Soc Neuroscience
Human epidemiological studies implicate exposure to infection during gestation in the
etiology of neurodevelopmental disorders. Animal models of maternal immune activation …

Altered dopamine D3 receptor gene expression in MAM model of schizophrenia is reversed by peripubertal cannabidiol treatment

T Stark, M Di Bartolomeo, R Di Marco… - Biochemical …, 2020 - Elsevier
Gestational methylazoxymethanol acetate (MAM) treatment produces offspring with adult
phenotype relevant to schizophrenia, including positive-and negative-like symptoms …

[HTML][HTML] Maternal immune activation during pregnancy impacts on brain structure and function in the adult offspring

S Kreitz, A Zambon, M Ronovsky, L Budinsky… - Brain, Behavior, and …, 2020 - Elsevier
Gestational infection constitutes a risk factor for the occurrence of psychiatric disorders in the
offspring. Activation of the maternal immune system (MIA) with subsequent impact on the …

The Poly I: C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats

M Casquero-Veiga, N Lamanna-Rama… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction: Prenatal infections are associated with an increased risk of the onset of
schizophrenia. Rodent models of maternal immune stimulation (MIS) have been extensively …

Gestational poly (I: C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat 'dual-hit'model for …

JY Goh, SE O'Sullivan, SE Shortall, N Zordan… - Brain, Behavior, and …, 2020 - Elsevier
Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental
risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have …

Gender-specific approach in psychiatric diseases: because sex matters

A Franceschini, L Fattore - European journal of pharmacology, 2021 - Elsevier
In both animals and human beings, males and females differ in their genetic background
and hormonally driven behaviour and show sex-related differences in brain activity and …

The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy

MJ Dolleman-van Der Weel, MP Witter - Neuroscience & Biobehavioral …, 2020 - Elsevier
Anatomical, electrophysiological and behavioral studies in rodents have shown that the
thalamic midline nucleus reuniens (RE) is a crucial link in the communication between …