Invadopodia are a subset of invadosomes that are implicated in the integration of signals
from the tumor microenvironment to support tumor cell invasion and dissemination. Recent …

When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …

Fibronectin (FN) is a major component of the tumor microenvironment, but its role in
promoting metastasis is incompletely understood. Here, we show that FN gradients elicit …

Cancer metastasis requires the invasion of tumor cells into the stroma and the directed
migration of tumor cells through the stroma toward the vasculature and lymphatics where …

Tumors often overcome the cytotoxic effects of chemotherapy through either acquired or
environment-mediated drug resistance. In addition, signals from the microenvironment …

Breast cancer stands as the most prevalent cancer in women globally, and contributes to the
highest percentage of mortality due to cancer-related deaths in women. Paclitaxel (PTX) is …

Macrophages represent a heterogeneous group of cells, capable of carrying out distinct
functions in a variety of organs and tissues. Even within individual tissues, their functions …

The process of intravasation involving transendothelial migration is a key step in metastatic
spread. How the triple cell complex composed of a macrophage, Mena over-expressing …

During metastasis to distant sites, tumor cells migrate to blood vessels. In vivo, breast tumor
cells utilize a specialized mode of migration known as streaming, where a linear assembly of …

Gene expression profiling has yielded expression signatures from which prognostic tests
can be derived to facilitate clinical decision making in breast cancer patients. Some of these …