Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome
E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …
Developmental programming, a pathway to disease
V Padmanabhan, RC Cardoso… - Endocrinology, 2016 - academic.oup.com
Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …
Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models
ASL Caldwell, LJ Middleton, M Jimenez, R Desai… - …, 2014 - academic.oup.com
Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a
range of reproductive, metabolic and endocrine defects including anovulation, infertility …
range of reproductive, metabolic and endocrine defects including anovulation, infertility …
Diverse roles for sex hormone-binding globulin in reproduction
GL Hammond - Biology of reproduction, 2011 - academic.oup.com
Sex hormone-binding globulin (SHBG) transports androgens and estrogens in blood and
regulates their access to target tissues. Hepatic production of SHBG fluctuates throughout …
regulates their access to target tissues. Hepatic production of SHBG fluctuates throughout …
The management of patients with polycystic ovary syndrome
CN Jayasena, S Franks - Nature Reviews Endocrinology, 2014 - nature.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. The
syndrome is typified by its heterogeneous presentation, which includes hirsutism (a function …
syndrome is typified by its heterogeneous presentation, which includes hirsutism (a function …
Sheep models of polycystic ovary syndrome phenotype
V Padmanabhan, A Veiga-Lopez - Molecular and cellular endocrinology, 2013 - Elsevier
Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …
women. Women with PCOS manifest both reproductive and metabolic defects. Several …
[HTML][HTML] Role of androgens in normal and pathological ovarian function
KA Walters - Reproduction, 2015 - rep.bioscientifica.com
Androgens mediate their actions via the androgen receptor (AR), a member of the nuclear
receptor superfamily. AR-mediated androgen action is essential in male reproductive …
receptor superfamily. AR-mediated androgen action is essential in male reproductive …
[HTML][HTML] Mechanisms of intergenerational transmission of polycystic ovary syndrome
DA Dumesic, LR Hoyos, GD Chazenbalk… - …, 2020 - rep.bioscientifica.com
Developmental origins of adult disease (DoHAD) refers to critical gestational ages during
human fetal development and beyond when the endocrine-metabolic status of the mother …
human fetal development and beyond when the endocrine-metabolic status of the mother …
Animal models of the polycystic ovary syndrome phenotype
V Padmanabhan, A Veiga-Lopez - Steroids, 2013 - Elsevier
The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high
prevalence among infertility disorders in women of reproductive age. Although there is …
prevalence among infertility disorders in women of reproductive age. Although there is …
[HTML][HTML] Animal models of polycystic ovary syndrome: a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk
D Shi, DF Vine - Fertility and sterility, 2012 - Elsevier
OBJECTIVE: To review rodent animal models of polycystic ovary syndrome (PCOS), with a
focus on those associated with the metabolic syndrome and cardiovascular disease risk …
focus on those associated with the metabolic syndrome and cardiovascular disease risk …