More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …

Polycystic ovary syndrome (PCOS) affects 5–10% of women of reproductive age, causing a
range of reproductive, metabolic and endocrine defects including anovulation, infertility …

Sex hormone-binding globulin (SHBG) transports androgens and estrogens in blood and
regulates their access to target tissues. Hepatic production of SHBG fluctuates throughout …

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. The
syndrome is typified by its heterogeneous presentation, which includes hirsutism (a function …

Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …

Androgens mediate their actions via the androgen receptor (AR), a member of the nuclear
receptor superfamily. AR-mediated androgen action is essential in male reproductive …

Developmental origins of adult disease (DoHAD) refers to critical gestational ages during
human fetal development and beyond when the endocrine-metabolic status of the mother …

The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high
prevalence among infertility disorders in women of reproductive age. Although there is …

OBJECTIVE: To review rodent animal models of polycystic ovary syndrome (PCOS), with a
focus on those associated with the metabolic syndrome and cardiovascular disease risk …