Thrombotic thrombocytopenic purpura (TTP; also known as Moschcowitz disease) is
characterized by the concomitant occurrence of often severe thrombocytopenia …

Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays
major functions in cellular physiology and metabolism as the prosthetic group of diverse …

Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are
diseases characterized by microvascular thrombosis, with consequent thrombocytopaenia …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Damage associated molecular patterns (DAMPs) are endogenous molecules originate from
damaged cells and tissues with the ability to trigger and/or modify innate immune responses …

Atypical hemolytic uremic syndrome (aHUS) is characterized by genetic and acquired
abnormalities of the complement system leading to alternative pathway (AP) overactivation …

The purpose of this study was to explore the role of the complement system in normal
human pregnancy and preeclampsia in a comprehensive manner, measuring circulating …

Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs)
other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients …

Background: Ultra‐large von Willebrand factor and deficiency of its cleaving protease are
important factors in the events leading to thrombotic microangiopathy; however, the …

Complement activation has a major role in thrombotic microangiopathy (TMA), a disorder
that can occur in a variety of clinical conditions. Promising results of recent trials with …