A handful of biological proton-selective ion channels exist. Some open at positive or
negative membrane potentials, others open at low or high pH, and some are light activated …

Natural protein channels have evolved with exquisite structures to transport ions selectively
and rapidly. Learning from nature to construct biomimetic artificial channels is always …

The mechanisms underlying sex determination are astonishingly plastic. Particularly the
triggers for the molecular machinery, which recalls either the male or female developmental …

The human voltage-gated proton channel Hv1 is a drug target for cancer, ischemic stroke,
and neuroinflammation. It resides on the plasma membrane and endocytic compartments of …

In oviparous marine fishes, the hyperosmotic induction of sperm motility in seawater (SW) is
well established, however, the potential function of ion channels in the maintenance of post …

The membrane potential of a cell (Vm) regulates several physiological processes. The
voltage sensor domain (VSD) is a region that confers voltage sensitivity to different types of …

Lysosome acidification is a dynamic equilibrium of H+ influx and efflux across the
membrane, which is crucial for cell physiology. The vacuolar H+ ATPase (V‐ATPase) is …

Despite the elucidation of the many processes by which a single eukaryotic cell develops
into a complex mature organism, it is still puzzling to some biologists how it is that an …

Voltage-gated ion channels allow ion flux across biological membranes in response to
changes in the membrane potential. HCNL1 is a recently discovered voltage-gated ion …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate electrical
rhythmicity in various tissues although primarily heart, retina and brain. The HCN channel …